Bayesian nonparametric learning of complex dynamical phenomena

Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2009.Cataloged from PDF version of thesis.Includes bibliographical references (p. 257-270).The complexity of many dynamical phenomena precludes the use of linear models for which exact analytic techniques are available. However, inference on standard nonlinear models quickly becomes intractable. In some cases, Markov switching processes, with switches between a set of simpler models, are employed to describe the observed dynamics. Such models typically rely on pre-specifying the number of Markov modes. In this thesis, we instead take a Bayesian nonparametric approach in defining a prior on the model parameters that allows for flexibility in the complexity of the learned model and for development of efficient inference algorithms. We start by considering dynamical phenomena that can be well-modeled as a hidden discrete Markov process, but in which there is uncertainty about the cardinality of the state space. The standard finite state hidden Markov model (HMM) has been widely applied in speech recognition, digital communications, and bioinformatics, amongst other fields. Through the use of the hierarchical Dirichlet process (HDP), one can examine an HMM with an unbounded number of possible states. We revisit this HDPHMM and develop a generalization of the model, the sticky HDP-HMM, that allows more robust learning of smoothly varying state dynamics through a learned bias towards self-transitions. We show that this sticky HDP-HMM not only better segments data according to the underlying state sequence, but also improves the predictive performance of the learned model. Additionally, the sticky HDP-HMM enables learning more complex, multimodal emission distributions.(cont.) We demonstrate the utility of the sticky HDP-HMM on the NIST speaker diarization database, segmenting audio files into speaker labels while simultaneously identifying the number of speakers present. Although the HDP-HMM and its sticky extension are very flexible time series models, they make a strong Markovian assumption that observations are conditionally independent given the discrete HMM state. This assumption is often insufficient for capturing the temporal dependencies of the observations in real data. To address this issue, we develop extensions of the sticky HDP-HMM for learning two classes of switching dynamical processes: the switching linear dynamical system (SLDS) and the switching vector autoregressive (SVAR) process. These conditionally linear dynamical models can describe a wide range of complex dynamical phenomena from the stochastic volatility of financial time series to the dance of honey bees, two examples we use to show the power and flexibility of our Bayesian nonparametric approach. For all of the presented models, we develop efficient Gibbs sampling algorithms employing a truncated approximation to the HDP that allows incorporation of dynamic programming techniques, greatly improving mixing rates. In many applications, one would like to discover and model dynamical behaviors which are shared among several related time series. By jointly modeling such sequences, we may more robustly estimate representative dynamic models, and also uncover interesting relationships among activities.(cont.) In the latter part of this thesis, we consider a Bayesian nonparametric approach to this problem by harnessing the beta process to allow each time series to have infinitely many potential behaviors, while encouraging sharing of behaviors amongst the time series. For this model, we develop an efficient and exact Markov chain Monte Carlo (MCMC) inference algorithm. In particular, we exploit the finite dynamical system induced by a fixed set of behaviors to efficiently compute acceptance probabilities, and reversible jump birth and death proposals to explore new behaviors. We present results on unsupervised segmentation of data from the CMU motion capture database.by Emily B. Fox.Ph.D

Detection and localization of aerosol releases from sparse sensor measurements

Thesis (M. Eng.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2005.This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.Includes bibliographical references (p. 111-114).In this thesis we focus on addressing two aspects pertinent to biological release detection. The first is that of detecting and localizing an aerosolized particle release using a sparse array of sensors. The problem is challenging for several reasons. It is often the case that sensors are costly and consequently only a sparse deployment is possible. Additionally, while dynamic models can be formulated in many environmental conditions, the underlying model parameters may not be precisely known. The combination of these two issues impacts the effectiveness of inference approaches. We restrict ourselves to propagation models consisting of diffusion plus transport according to a Gaussian puff model. We derive optimal inference algorithms utilizing sparse sensor measurements, provided the model parameterization is known precisely. The primary assumptions are that the mean wind field is deterministically known and that the Gaussian puff model is valid. Under these assumptions, we characterize the change in performance of detection, time-to-detection and localization as a function of the number of sensors. We then examine some performance impacts when the underlying dynamical model deviates from the assumed model. In addition to detecting an abrupt change in particles in an environment, it is also important to be able to classify the releases as not all contaminants are of interest. For this reason, the second aspect of addressed is feature extraction, a stage where sensor measurements are reduced to a set of pertinent features that can be used as an input to the classifier.(cont.) Shift invariance of the feature set is critical and thus the Dual Tree Complex Wavelet Transform (DT CWT) is proposed as the wavelet feature domain.by Emily Beth Fox.M.Eng

MFA10 (MFA 2010)

Catalogue of a culminating student exhibition held at the Mildred Lane Kemper Art Museum in 2010. Content includes Foreword / Buzz Spector -- Thinking as making / Robert Gero -- A new set of conversations / Patricia Olynyk -- MFA 2010 graduates. Clyde Ashby / Aaron Bos-Wahl / Andrew Cozzens / John Early / Ryan James Fabel / Joel Fullerton / Mary Beth Hassan / Wenting Hsu / John Nicholas Hutchings/ Dani Kantrowitz / Larry Keaty / Mamie Korpela / Paola Laterza / Mad Mohre / Emily Moorhead / Jonathan Muehlke / Jessa Richardson / Nicolette Ross / Carlie Trosclair / About the Sam Fox School.https://openscholarship.wustl.edu/books/1007/thumbnail.jp

LSST Science Book, Version 2.0

A survey that can cover the sky in optical bands over wide fields to faint magnitudes with a fast cadence will enable many of the exciting science opportunities of the next decade. The Large Synoptic Survey Telescope (LSST) will have an effective aperture of 6.7 meters and an imaging camera with field of view of 9.6 deg^2, and will be devoted to a ten-year imaging survey over 20,000 deg^2 south of +15 deg. Each pointing will be imaged 2000 times with fifteen second exposures in six broad bands from 0.35 to 1.1 microns, to a total point-source depth of r~27.5. The LSST Science Book describes the basic parameters of the LSST hardware, software, and observing plans. The book discusses educational and outreach opportunities, then goes on to describe a broad range of science that LSST will revolutionize: mapping the inner and outer Solar System, stellar populations in the Milky Way and nearby galaxies, the structure of the Milky Way disk and halo and other objects in the Local Volume, transient and variable objects both at low and high redshift, and the properties of normal and active galaxies at low and high redshift. It then turns to far-field cosmological topics, exploring properties of supernovae to z~1, strong and weak lensing, the large-scale distribution of galaxies and baryon oscillations, and how these different probes may be combined to constrain cosmological models and the physics of dark energy.Comment: 596 pages. Also available at full resolution at http://www.lsst.org/lsst/sciboo

Effects of antiplatelet therapy on stroke risk by brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases: subgroup analyses of the RESTART randomised, open-label trial

Background Findings from the RESTART trial suggest that starting antiplatelet therapy might reduce the risk of recurrent symptomatic intracerebral haemorrhage compared with avoiding antiplatelet therapy. Brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases (such as cerebral microbleeds) are associated with greater risks of recurrent intracerebral haemorrhage. We did subgroup analyses of the RESTART trial to explore whether these brain imaging features modify the effects of antiplatelet therapy

Male breast cancer in BRCA1 and BRCA2 mutation carriers : pathology data from the Consortium of Investigators of Modifiers of BRCA1/2

Background: BRCA1 and, more commonly, BRCA2 mutations are associated with increased risk of male breast cancer (MBC). However, only a paucity of data exists on the pathology of breast cancers (BCs) in men with BRCA1/2 mutations. Using the largest available dataset, we determined whether MBCs arising in BRCA1/2 mutation carriers display specific pathologic features and whether these features differ from those of BRCA1/2 female BCs (FBCs). Methods: We characterised the pathologic features of 419 BRCA1/2 MBCs and, using logistic regression analysis, contrasted those with data from 9675 BRCA1/2 FBCs and with population-based data from 6351 MBCs in the Surveillance, Epidemiology, and End Results (SEER) database. Results: Among BRCA2 MBCs, grade significantly decreased with increasing age at diagnosis (P = 0.005). Compared with BRCA2 FBCs, BRCA2 MBCs were of significantly higher stage (P for trend = 2 x 10(-5)) and higher grade (P for trend = 0.005) and were more likely to be oestrogen receptor-positive [odds ratio (OR) 10.59; 95 % confidence interval (CI) 5.15-21.80] and progesterone receptor-positive (OR 5.04; 95 % CI 3.17-8.04). With the exception of grade, similar patterns of associations emerged when we compared BRCA1 MBCs and FBCs. BRCA2 MBCs also presented with higher grade than MBCs from the SEER database (P for trend = 4 x 10(-12)). Conclusions: On the basis of the largest series analysed to date, our results show that BRCA1/2 MBCs display distinct pathologic characteristics compared with BRCA1/2 FBCs, and we identified a specific BRCA2-associated MBC phenotype characterised by a variable suggesting greater biological aggressiveness (i.e., high histologic grade). These findings could lead to the development of gender-specific risk prediction models and guide clinical strategies appropriate for MBC management.Peer reviewe

Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast-ovarian cancer susceptibility locus

A locus at 19p13 is associated with breast cancer (BC) and ovarian cancer (OC) risk. Here we analyse 438 SNPs in this region in 46,451 BC and 15,438 OC cases, 15,252 BRCA1 mutation carriers and 73,444 controls and identify 13 candidate causal SNPs associated with serous OC (P=9.2 × 10-20), ER-negative BC (P=1.1 × 10-13), BRCA1-associated BC (P=7.7 × 10-16) and triple negative BC (P-diff=2 × 10-5). Genotype-gene expression associations are identified for candidate target genes ANKLE1 (P=2 × 10-3) and ABHD8 (P<2 × 10-3). Chromosome conformation capture identifies interactions between four candidate SNPs and ABHD8, and luciferase assays indicate six risk alleles increased transactivation of the ADHD8 promoter. Targeted deletion of a region containing risk SNP rs56069439 in a putative enhancer induces ANKLE1 downregulation; and mRNA stability assays indicate functional effects for an ANKLE1 3′-UTR SNP. Altogether, these data suggest that multiple SNPs at 19p13 regulate ABHD8 and perhaps ANKLE1 expression, and indicate common mechanisms underlying breast and ovarian cancer risk

The Science Performance of JWST as Characterized in Commissioning

This paper characterizes the actual science performance of the James Webb Space Telescope (JWST), as determined from the six month commissioning period. We summarize the performance of the spacecraft, telescope, science instruments, and ground system, with an emphasis on differences from pre-launch expectations. Commissioning has made clear that JWST is fully capable of achieving the discoveries for which it was built. Moreover, almost across the board, the science performance of JWST is better than expected; in most cases, JWST will go deeper faster than expected. The telescope and instrument suite have demonstrated the sensitivity, stability, image quality, and spectral range that are necessary to transform our understanding of the cosmos through observations spanning from near-earth asteroids to the most distant galaxies.Comment: 5th version as accepted to PASP; 31 pages, 18 figures; https://iopscience.iop.org/article/10.1088/1538-3873/acb29

Effects of antiplatelet therapy after stroke due to intracerebral haemorrhage (RESTART): a randomised, open-label trial

Background: Antiplatelet therapy reduces the risk of major vascular events for people with occlusive vascular disease, although it might increase the risk of intracranial haemorrhage. Patients surviving the commonest subtype of intracranial haemorrhage, intracerebral haemorrhage, are at risk of both haemorrhagic and occlusive vascular events, but whether antiplatelet therapy can be used safely is unclear. We aimed to estimate the relative and absolute effects of antiplatelet therapy on recurrent intracerebral haemorrhage and whether this risk might exceed any reduction of occlusive vascular events. Methods: The REstart or STop Antithrombotics Randomised Trial (RESTART) was a prospective, randomised, open-label, blinded endpoint, parallel-group trial at 122 hospitals in the UK. We recruited adults (≥18 years) who were taking antithrombotic (antiplatelet or anticoagulant) therapy for the prevention of occlusive vascular disease when they developed intracerebral haemorrhage, discontinued antithrombotic therapy, and survived for 24 h. Computerised randomisation incorporating minimisation allocated participants (1:1) to start or avoid antiplatelet therapy. We followed participants for the primary outcome (recurrent symptomatic intracerebral haemorrhage) for up to 5 years. We analysed data from all randomised participants using Cox proportional hazards regression, adjusted for minimisation covariates. This trial is registered with ISRCTN (number ISRCTN71907627). Findings: Between May 22, 2013, and May 31, 2018, 537 participants were recruited a median of 76 days (IQR 29–146) after intracerebral haemorrhage onset: 268 were assigned to start and 269 (one withdrew) to avoid antiplatelet therapy. Participants were followed for a median of 2·0 years (IQR [1·0– 3·0]; completeness 99·3%). 12 (4%) of 268 participants allocated to antiplatelet therapy had recurrence of intracerebral haemorrhage compared with 23 (9%) of 268 participants allocated to avoid antiplatelet therapy (adjusted hazard ratio 0·51 [95% CI 0·25–1·03]; p=0·060). 18 (7%) participants allocated to antiplatelet therapy experienced major haemorrhagic events compared with 25 (9%) participants allocated to avoid antiplatelet therapy (0·71 [0·39–1·30]; p=0·27), and 39 [15%] participants allocated to antiplatelet therapy had major occlusive vascular events compared with 38 [14%] allocated to avoid antiplatelet therapy (1·02 [0·65–1·60]; p=0·92). Interpretation: These results exclude all but a very modest increase in the risk of recurrent intracerebral haemorrhage with antiplatelet therapy for patients on antithrombotic therapy for the prevention of occlusive vascular disease when they developed intracerebral haemorrhage. The risk of recurrent intracerebral haemorrhage is probably too small to exceed the established benefits of antiplatelet therapy for secondary prevention